| 摘要 |
PROBLEM TO BE SOLVED: To obtain 1,5-benzodiazepine derivative, useful as an intermediate for a pharmaceutical compound for angina pectoris, etc., by using a specific new compound as a raw material. SOLUTION: This 1,5-benzodiazepine derivative of formula II [ring A and ring B are each a (substituted) benzene ring; R<1> and R<2> are each H, carbamoyl, etc.; R<3> is H, a di-(lower alkyl) amino(lower alkyl), etc.] or its salt is obtained by subjecting a propionic acid amide expressed by formula I or its salt to an intramolecular ring closing reaction. The reaction is carried out in the presence of an acid such as a Broensted acid or a base such as alkali metal hydrogencarbonate in a solvent such as methanol at 0-250 deg.C. Further, a new compound of formula I is obtained by reacting 2-aminothiophenol derivative of formula III with 2,3-epoxypropionic acid amide derivative of formula IV. |
