| 摘要 |
A pharmaceutical compound having the formula (see fig. I) in which R1 is alkyl, -SO2R14 where R14 is alkyl, optionally substituted aryl or optionally substituted heteroaryl, R2 is hydrogen, alkyl optionally substituted with one or more hydroxy or C1-4 alkoxy groups, optionally substituted aryl, optionally substituted heteroaryl, -OR15, -P(O)(OR15) (OR16) or -NR15R16 where R15 and R16 are each hydrogen or alkyl, or -SO2R17 where R17 is hydrogen, alkyl, optionally substituted aryl or optionally substituted heteroaryl, R3 is hydrogen, -CN, -CO2R18, -CONR18R19,-CH18~CHR19, -C~CR18, -OCH2CO.R18, -SO2R18 -CH2OR18, -CH2OCO.R18, -CH2NHCOR18, -CH2N(COR18)2, -CHO, -OR18, -CH2NR18R19, -CH2OR18, -CH=NR18 or -CH=N-OR18, where R18 and R19 are each hydrogen or alkyl, x is a bond or -SO2-, R4, R5, R6, R8, R9 and R10 are each hydrogen or alkyl, n is 1 to 4, A is -CH2- or -YCO- where Y is a bond, -O-, optionally substituted phenylene, -CH=CH-, or -NR20- where R20 is hydrogen or alkyl, R7 is the C-.alpha. substituent of an amino acid or an ester thereof, or R6 and R7 together form a C3-5 alkylene chain optionally substituted by C1-4 alkyl or hydroxyl, or a group of the formula -CH2-Z-CH2- where Z is -CO-, -S-, -SO-or -SO2-, or R7 and R8 together form a C3 to C5 alkylene chain optionally substituted by C1-4 alkyl or hydroxyl, B is -CON(R21)-, -CON(R21)N(R22)- or (see fig. I) where -x=y- is -C(R22)=N-, -N=C(R22)- or -N=N-, where R 21 is hydrogen, alkyl or -NR23R24 where R23 and R24 are each hydrogen or alkyl, and where R22 is hydrogen or alkyl, or R8 and R21 together form a C2-4 alkylene chain, m is 0 to 2, R11 is hydrogen or alkyl, R12 is hydrogen, alkyl, optionally substituted aryl, optionally substituted heteroaryl, -CN, -OH, -CO2R25 , -CONR25R26 , where R25 and R26 are each hydrogen or alkyl, and R13 is alkyl, optionally substituted aryl or optionally substituted heteroaryl, or R12 and R13 together form a C3-8 cycloalkyl group or C3-8 cycloalkyl fused to optionally substituted phenyl; or a salt or ester thereof.
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