| 摘要 |
<p>A substituted thiazolo[3,2-'alpha']azepine derivative represented by general formula (I) and having the effect of inhibiting an agiotensin I-converting enzyme and an atrial natriuretic peptide hydrolase, wherein R1 represents hydrogen or a thiol-protective group; R2 represents hydrogen, lower alkyl, optionally substituted aryl, optionally substituted heteroaryl, lower alkoxy or lower alkylthio; R3, R4 and R5 represent each independently hydrogen, lower alkyl, lower alkoxy, lower alkylthio, etc., provided the case where all of R3, R4 and R5 are hydrogen atoms at the same time is excepted; R6 and R7 represent each independently hydrogen or lower alkyl; R8 represents hydrogen or a carboxyl-protective group; and m and n represent each independently 0, 1 or 2.</p> |
