| 摘要 |
The present invention refers to new imidazopyridines of formula (I); wherein: one of A, B, C, and D and the remaining are CR, R being hydrogen; C1-4 alkyl, COOH or halogen; R1 represents C1-4 alkyl or C3-7 cycloalkyl; Ar1 represents optionally substituted phenyl or pyridine; V represents C1-4 alkyl, C3-7 cycloalkyl, aryl, aryl-(C1-4)alkyl, or a 5 or 6-membered aromatic heterocycle; X-Y represents C=C or CH-CR3; R3 represents hydrogen, C1-4 alkyl or aryl-(C1-4)alkyl; Z represents among others -CO2R4, -tetrazole-5-yl, -CONHSO2R4, -CONR4R5, -CH2NHSO2R4; R4 and R5 represent hydrogen, C1-4 alkyl, aryl, aryl-(C1-4)alkyl or perfluoro-(C1-4)alkyl; W represents hydrogen, cyan, C1-4-alkyl, C1-4 alkyl, C1-4 haloalkyl, C3-7 cycloalkyl, aryl, aryl-(C1-4)alkyl, C1-4 alkylsulfonium, C1-4 alkylsulfinyl, C1-4 alkylthio, C1-4 alkoxy, C1-4 alkylcarbonyl, halogen, hydroxymethyl or C1-4 alkoxymethyl, or W can represent any of Z meanings. These compounds are angiotensine II antagonists.
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