Phenyl or phenylalkyl substituted naphtalene derivatives having retinoid-like activity as well as anti-tumor activities.

摘要

This invention relates to a retinoid compound of formula I in which Y is -CO-NH-, -CR<2>=CR<3>-, -CO-O-, -O-CO-, -C(=S)-NH-, -C IDENTICAL C-, -O-CH2-, -CH2-O-, or -CH2-CH2-; A is -(CH2)t- or a bond; Q is phenyl optionally substituted with one to three same or different C1-6alkyl, C1-6alkoxy, halogen, or -CO2R<4>; R<1> is -CO2Z, -CONHR<5>, C1-6alkyl, -CH2OH, or -CHO; R<2>, R<3>, R<4>, R<5>, and Z are independently hydrogen or C1-6alkyl; t is one to six.