AZAASPARTIC ACID ANALOGS AS INTERLEUKIN-1 BETA CONVERTING ENZYME INHIBITORS.

摘要

Disclosed are compounds, compositions and methods for inhibiting interleukin-1 'beta' protease activity. The compounds, 'alpha'-substituted acetamides are of formula (A), wherein: R2 = H or alkyl; R3 = halo, O(CO)0-1aryl, OPOR4R5; (a), (b) where R4 and R5 = aryl; R6 = H, aryl or aralkyl; R7 = independently selected from R6, CF3 and CF2CF3; R1 = R6-CO, heteroaryl-CO, heteroaralkyl-CO and amino acid.