VIRAL VECTORS INCLUDING POLYNUCLEOTIDES ENCODING NEUROTROPHIC FACTORS AND USES THEREFOR

摘要

Viral vectors such as, for example, retroviral vectors, adenoviral vectors, SV40 vectors, and Herpes Virus vectors, which include a polynucleotide encoding a neurotrophic factor, such as, glial cell line derived neurotrophic factor (GDNF). Such vectors may be employed in gene therapy procedures for the treatment of amyotrophic lateral sclerosis or Parkinson's Disease, wherein such vectors are employed in the ex vivo or in vivo transduction of cells.