发明名称 |
MUTATED RAS PEPTIDES FOR GENERATION OF CD8<+> CYTOTOXIC T LYMPHOCYTES |
摘要 |
Mutant ras oncogene peptides may induce specific ant-ras cellular immune responses in vaccinated patients. Moreover, a human CD8<+> CTL epitope(s) reflecting a specific point mutation in the K-ras oncogene at codon 12 was identified. The mutant ras peptide has implications for both active and passive immunotherapies in selected carcinoma patients. A nested 10-mer peptide was identified [i.e., ras5-14(Asp12)], which was shown to bind to HLA-A2 and display specific functional capacity for expansion of the in-vivo-primed CD8<+> CTL precursors. |
申请公布号 |
WO9740156(A1) |
申请公布日期 |
1997.10.30 |
申请号 |
WO1997US06470 |
申请日期 |
1997.04.17 |
申请人 |
THE GOVERNMENT OF THE UNITED STATES OF AMERICA, RE;SCHLOM, JEFFREY;ABRAMS, SCOTT |
发明人 |
SCHLOM, JEFFREY;ABRAMS, SCOTT |
分类号 |
A61K39/00;C07K14/82;C12N5/08;C12N15/12;(IPC1-7):C12N15/12;A61K45/05;A61K38/17 |
主分类号 |
A61K39/00 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|