DETECTION OF VARIATIONS IN HUMAN H2 RECEPTORS

摘要

A group of oligonucleotides for the identification of sequences in a sample comprising human histamine H2 receptor DNA, cDNA or RNA originating from a tissue sample or body fluid is employed in the diagnosis and/or treatment of human neurological and psychiatric disorders, particularly schizophrenia, and diseases of other systems or organs of the human body. The new oligonucleotides, suitable for use as primers for the amplification of DNA corresponding to a region of a human histamine H2 receptor, have nucleotide sequences selected from: 5' ACACCAGCCTGGATGTGA 3' (as listed in SEQ ID NO:12), 5' TCACATCCAGGCTGGTGT 3' (as listed in SEQ ID NO:13), 5' CAATCATACCACCTCTAA 3' (as listed in SEQ ID NO:14), 5' ACACAAACGCGGTGAAGT 3' (as listed in SEQ ID NO:15). Also described is a diagnostic kit comprising one or more of the above mentioned oligonucleotides.