1-(4-PIPERIDYL)-BENZIMIDAZOLES HAVING NEUROTROPHIC ACTIVITY

摘要

The present invention discloses compounds of formula (I) wherein the dotted bonds are optional extra bonds allowing any tautomeric isomers compatible with substituents X and R<3>; R<3> is non-existing, hydrogen, or alkyl; X is O, S, imino, alkoxy, alkylthio, or amino; R<1> is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, acyl, acylalkyl, alkoxyalkyl, dialkoxyalkyl, or phenylalkyl which may be substituted with alkyl, halogen, amino, nitro or cyano; and R<4>, R<5>, R<6> and R<7> independently of each other are hydrogen, halogen, amino, nitro, CN, CF3, COOH, COO-alkyl, alkyl, acyl, alcoxy, -(CH2)n, -OH wherein n is 0, 1, 2 or 3; -(CH2)m-O-alkyl wherein m is 0, 1, 2 or 3; -(CH2)p-O-acyl wherein p is 0, 1, 2 or 3; or a pharmaceutically acceptable addition salt thereof. The compounds are useful as pharmaceuticals, for example, in the treatment of traumatic lesions of peripheral nerves, the medulla, and/or the spinal cord, cerebral ischaemic neuronal damage, neuropathy and especially peripheral neuropathy, dementia, Alzheimer's disease, Huntington's disease, Parkinson's disease, amyotrophic lateral sclerosis, or any other neurodegenerative disease.