Verfahren zur Senkung des Blutglukosespiegels in Säugern

摘要

The invention relates to the use of a method in which by reducing in the blood of a mammal by administration of effectors the enzyme activity of dipeptidyl peptidase (DP IV) or enzyme activity similar to DP IV, the endogenous (or additionally exogenously administered) insulinotropic peptide gastric inhibitory polypeptide 1-42 (GIP1-42) and glucagon-like peptide amide-1 7-36 (GLP-17-36) (or similarly GLP-17-37 or analogues thereof) are decomposed in a causal sequence to a reduced extent by DP IV enzymes or those similar to DP IV. Consequently, the fall in the concentration of said peptide hormones or the analogues thereof is reduced or retarded. The increased stability, achieved by the action of DP IV effectors, of the incretine or the analogues thereof which are available endogenously or exogenously and consequently provided in increased numbers for insulinotropic stimulation of the incretine receptors of the Langerhans cells in the pancreas, changes the power of endogenous insulin thereby stimulating the metabolism of carbohydrates in the treated organism. The blood sugar level therefore drops below the glucose concentration, characteristic of hyperglycaemia, in the serum of the treated organism. Metabolic anomalies such as glucosuria, hyperlipidemia, possible serious metabolic acidosis, diabetes mellitus, which result from higher concentrations of glucose in the blood over a longer period of time, are prevented or alleviated. The method according to the invention is a novel way of lowering high blood glucose concentrations. It is simple, commercially applicable and suitable for use in human medicine for treating, in particular diseases caused by above-average blood glucose levels.