发明名称 |
NOVEL PEPTIDES SUITABLE FOR USE IN ANTIGEN SPECIFIC IMMUNOSUPPRESSIVE THERAPY |
摘要 |
The invention relates to peptides consisting of 16 to 55 amino acid residues, said peptides comprising at least one of the amino acid sequences LVCYYTSWS (SEQ ID NO:60), FLCTHIIYS (SEQ ID NO:61), IIYSFANIS (SEQ ID NO:62), LKTLLSVGG (SEQ ID NO:63), FIKSVPPFL (SEQ ID NO:64), FDGLDLAWL (SEQ ID NO:65), LYPGRRDKQ (SEQ ID NO:66), YDIAKISQH (SEQ ID NO:67), LDFISIMTY (SEQ ID NO:68), FISIMTYDF (SEQ ID NO:69), FRGQEDASP (SEQ ID NO:70), YAVGYMLRL (SEQ ID NO:71), MLRLGAPAS (SEQ ID NO:72), LAYYEICDF (SEQ ID NO:73), LRGATVHRT (SEQ ID NO:74), YLKDRQLAG (SEQ ID NO:75), LAGAMVWAL (SEQ ID NO:76), VWALDLDDF (SEQ ID NO:77) or LDLDDFQGS (SEQ ID NO:78). The peptides can be used in the treatment of T-cell mediated destruction of articular cartilage. Administration of pharmaceutical compositions based on these peptides can be used to induce systemic immunological tolerance to the autoantigens under attack of the autoreactive T-cells.
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申请公布号 |
WO9740068(A1) |
申请公布日期 |
1997.10.30 |
申请号 |
WO1997EP02051 |
申请日期 |
1997.04.22 |
申请人 |
AKZO NOBEL N.V.;BOOTS, ANNA, MARIA, HELENA;VERHEIJDEN, GIJSBERTUS, FRANCISCUS, MARIA |
发明人 |
BOOTS, ANNA, MARIA, HELENA;VERHEIJDEN, GIJSBERTUS, FRANCISCUS, MARIA |
分类号 |
A61K38/00;A61K31/00;A61K38/17;A61K49/00;A61P19/02;A61P37/00;A61P37/06;C07K7/08;C07K14/47;G01N33/68;(IPC1-7):C07K14/47 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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