| 摘要 |
The invention provides a highly conserved, immunologically accessible antigen at the surface of Neisseria meningitidis organisms. Immunotherapeutic, prophylactic and diagnostic compositions and methods is useful in the treatment, prevention and diagnosis of Neisseria meningitidis diseases. A proteinase resistant Neisseria meningitidis surface protein having an apparent molecular weight of 22 kDa, the corresponding nucleotide and derived amino acid sequences (SEQ ID NO:1, NO:3, NO:5, and NO:7: SEQ ID NO:2, NO:4, NO:6, and NO:8), recombinant DNA methods for the production of the Neisseria meningitidis 22 kDa surface protein, and antibodies that bind to the Neisseria meningitidis 22 kDa surface protein. |
