CAMPTOTHECIN DERIVATIVES AND ITS MANUFACTURING METHOD

摘要

Intermediates for the synthesis of camptothecin of the formula IIwherein:R1 is -(CH2)2NR1R2, where R1 is an amino protecting group and R2 is C2-C5 alkyl, hydroxyethyl or acetoxyethyl group, and of the formula IIIwherein:n is 1 or 2;R3 is hydrogen or -OR4, where R4 is hydrogen, -COR5, -CONHR6 or CH2OR7, where R5 is methyl or -CH2OCH3, R6 is isopropyl, phenyl or -CH2CH2Cl, and R7 is methyl, ethyl or -CH2CH2OCH3; with the proviso that when n is 2, R3 is not hydrogen.