发明名称 HEW HYDANTOIN DERIVATIVE, AND ULTRAVIOLET RAYS ABSORBING AGENT AND AGENT FOR EXTERNAL USE FOR SKIN
摘要 PROBLEM TO BE SOLVED: To obtain the subject new specific derivative having a water solubility, manifesting an excellent ultraviolet rays absorbing activity having a maximum absorption in a UV-A region, and useful as an ultraviolet rays absorption agent and an agent for external use for skin blended with the same. SOLUTION: This new hydantoin derivative expressed by formula I [A is a residue obtained by removing (n) hydroxyl groups from an alkylglycoside having a 1-20C alkyl group; X is H, OH, a methyleneoxide, a 1-20C hydrocarbon and a 1-20C alkoxy; Y is an alkylene; (a) is an integer of 1-5; (n) is an integer], has an activity to absorb ultraviolet rays in a UV-A region, and is useful as an ultraviolet rays absorbing agent and an agent for external use for skin blended with the same. The compound is obtained by heating for reacting a hydantoin carboxylic ester derivative expressed by formula II (R is a lower alkyl) with an alkylglycoside in the presence of a base in a solvent such as N,N-dimethylformamide at 100οC.
申请公布号 JPH09278788(A) 申请公布日期 1997.10.28
申请号 JP19960115572 申请日期 1996.04.11
申请人 KANEBO LTD 发明人 NISHIO HIROYUKI;IKEMOTO TAKESHI;NAKATSUGAWA HIROKO
分类号 C07H15/26;A61K8/00;A61K8/60;A61K8/73;A61K31/70;A61K31/7028;A61P17/00;A61Q17/04;A61Q19/00;C09K3/00;(IPC1-7):C07H15/26;A61K7/00;A61K7/42;A61K7/48 主分类号 C07H15/26
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