摘要 |
PROBLEM TO BE SOLVED: To obtain a new phenol derivative having excellent lipid peroxidation suppressive activity and macrophage foaming suppressive activity, and useful for preventing/treating ischemic cardiopathy, etc., by reaction of a specific compound with phosgene and so forth. SOLUTION: This new phenol derivative is expressed by formula I [R<0> is H, a lower alkyl or a lower alkoxy; R<1> is a lower alkyl; W is O, S or NR<5> (R<5> is H, a lower alkyl, etc.); R<21> is a substituted alkyl; R<3> is H or a (substituted) lower alkyl], e.g. 2- 3-[2-(4-ethoxycarbonyl methoxyphenyl)ethyl]ureido}-4- methoxyphenol. The phenol derivative is obtained by reaction of a compound (salt) of formula II (R<4> is an OH-protecting group) with phosgene, triphosgene or thiophosgene followed by reaction with a compound of formula III to form a compound of formula IV, then eliminating protecting group therefrom. |