| 摘要 |
PROBLEM TO BE SOLVED: To prepare a new compound expressed by a specified formula. capable of efficiently forming a complex in combination with an expression vector including a gene of a biological activator, capable of efficiently transfecting the gene into a target cell and useful as a component of a liposome membrane. SOLUTION: This compound is expressed by the formula [R is a 10∼22C (un)saturated aliphatic hydrocarbon; (n)>=3; Z is N(R<1> )2 or N<+> (R<1> )3 (R<1> is a 1∼6C alkyl)]. The compound is preferably obtained by e.g. reaction of dihydroxyacetone as a starting material with a fatty acid for acylation to produce diacetoxyacetone, followed by its reduction to produce 1,3-diacylated glycerol, by esterification of a free OH group with a preferred halogenated product of a fatty acid and then by introducing an ammonium or amino group into a terminal site of the esterified product of the fatty acid. It is preferable to make one, or two or more selected from a group of the resultant compounds include in a quantity of 5∼50mol% based on the total quantity of lipid to produce the objective liposome.
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