| 摘要 |
A miniaturized brush and method of making same having a hollow lumen for introducing an agent for dissolving a soft fibrinous obstruction, such as a recently formed thrombus, within a patient's vascular system. The brush has soft, flexible bristles extending outward from the drive shaft distal section, the bristles being sufficiently resilient and dimensioned for enabling compression and passage of the brush out of and back into the distal end of an introducer lumen and to mix into the fibrin of the soft thrombus, yet not damage the vessel wall. The brush assembly is formed of a proximal section comprising an elongated proximal tube and a distal section comprising a distal tube extension, the proximal and distal sections having an aligned lumen and forming a drive shaft or brush body. The brush is formed of brush bristles entrapped between coiled wire turns of a metal having enhanced radiographic imaging characteristics wound about the outer wall of the distal tube extension and distributed in a uniform pattern or in a helical pattern around the circumference of the outer wall to form a helical brush. The distal tube extension may be a continuation of the elongated proximal tube and the coiled wire may be wound about the outer wall of the proximal tube. Alternatively, a separate distal tube extension may be attached to a reinforced proximal tube and the coiled wire may be wound about the distal tube extension and a portion of the distal end of the proximal tube.
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