Benzodiazepine derivatives

摘要

PCT No. PCT/GB93/00599 Sec. 371 Date Sep. 20, 1994 Sec. 102(e) Date Sep. 20, 1994 PCT Filed Mar. 23, 1993 PCT Pub. No. WO93/19052 PCT Pub. Date Sep. 30, 1993 <IMAGE> (I) <IMAGE> (II) <IMAGE> (III) Compounds of Formula (I), and salts and prodrugs thereof, wherein said formula, R1 represents certain optionally substituted alkyl or C3-7cycloalkyl; R2 represents (II) or (III), where m is 0, 1, 2 or 3; R9 is H or C1-6alkyl; R10 is imidazolyl, triazolyl or tetrazolyl, and R11 is H, C1-6alkyl or halo; R3 is C1-6alkyl, halo or NR6R7; R4 is C1-7alkyl, C3-10cycloalkyl, C3-10cycloalkylC1-4alkyl, C6-10bicycloalkyl, optionally substituted aryl, or NR12R13; R5 is H or C1-4alkyl; n is 0, 1, 2 or 3; which are CCK and/or gastrin antagonists useful in therapy.