发明名称 |
Methods for enhanced production of tissue plasminogen activator in cell culture using alkanoic acids or salts thereof |
摘要 |
Methods for enhancing the production of tissue plasminogen activator (TPA) in cell culture are disclosed. The methods involve culturing TPA-producing cells in growth media supplemented with an alkanoic acid or salt thereof at a concentration which enhances TPA production. The most preferred methods utilize butyric acid or sodium butyrate at a concentration of between 0.5 mM and 2.5 mM.
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申请公布号 |
US5681718(A) |
申请公布日期 |
1997.10.28 |
申请号 |
US19940358552 |
申请日期 |
1994.12.14 |
申请人 |
CELLTECH LIMITED |
发明人 |
FIELD, RAYMOND PAUL |
分类号 |
C07K14/52;C07K14/61;C07K16/00;C07K16/06;C07K16/34;C12N1/38;C12N5/16;C12N9/72;C12P21/04;(IPC1-7):C12P21/00 |
主分类号 |
C07K14/52 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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