摘要 |
<p>Disclosed are compounds of formula (I) or the pharmaceutically acceptable acid addition salts thereof wherein: R1, R2, R3, R4, R5, R6, and R7 are the same or different and represent hydrogen, halogen, alkyl, alkoxy, hydroxy, cyano, nitro, trifluoromethyl, trifluoromethoxy; -O2CR', -NHCOR', -COR', -SOmR', where R' is C1-C6alkyl and wherein m is 0, 1 or 2; or R1, R2, R3, R4, R5, R6, and R7 independently represent -CONR'R'', or -NR'R'' where R' and R'' independently represent hydrogen or C1-C6alkyl; R8 is hydrogen or lower alkyl; X represents an optionally substituted alkylene group; and Y represents a mono-, di- or trisubstituted cyclic amino group, which compounds are useful in the treatment of affective disorders such as schizophrenia, depression, Alzheimer's disease, movement disorders such as Parkinsonism and dystonia, and other disorders which respond to dopaminergic blockade such as substance abuse and obsessive compulsive disorders. Further, compounds of this invention may be useful in treating the extrapyramidal side effects associated with the use of conventional neuroleptic agents.</p> |