发明名称 |
SYNTHESIS OF HUMAN PROCOLLAGENS AND COLLAGENS IN RECOMBINANT DNA SYSTEMS |
摘要 |
Methods of making collagen with hosts, and vectors that express collagen, and collagen post-translation enzymes are disclosed. Collagen post-translation enzymes include prolyl-4-hydroxylase, lysyl hydroxylase, lysyl oxidase, C-proteinase, and N-proteinase, and these enzymes increase the yield of properly folded, recombinant collagen in non-mammalian hosts. The collagens produced by these methods, hosts, and vectors include both homotrimer and heterotrimer collagen made from single or multiple collagen genes, respectively.
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申请公布号 |
WO9738710(A1) |
申请公布日期 |
1997.10.23 |
申请号 |
WO1997US07300 |
申请日期 |
1997.04.11 |
申请人 |
FIBROGEN, INC.;ACADEMY OF FINLAND;KIVIRIKKI, KARI, I.;PIHLAJANIEMI, TAINA |
发明人 |
KIVIRIKKI, KARI, I.;PIHLAJANIEMI, TAINA |
分类号 |
C12N15/09;C07K14/78;C12N1/19;C12N5/10;C12N9/02;C12P21/02;C12R1/645;C12R1/91;(IPC1-7):A61K38/39;A61K38/17;C12P21/00 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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