摘要 |
The invention relates to mammalian cell lines and transgenic mammals. More particularly, it relates to a method for producing a rat cell line, a method for producing a transgenic rat, a transgenic rat, a rat cell line, cells and tissue obtained therefrom and uses therefore. The cell line derived from a transgenic mammal comprises: (i) a conditional oncogene, transforming gene or immortalising gene or a cell cycle affecting gene; and (ii) a cell type specific promoter. They include a neuronal cell line in which the cell type specific promoter is an NF-L gene promoter, and a mammary cell line in which the cell type specific promoter is a MMTV gene promoter. The conditional oncogene, transforming gene or immortalising gene is preferably a SV40tsA58 gene.
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申请人 |
THE UNIVERSITY OF LIVERPOOL;RUDLAND, PHILIP, SPENCER;BARRACLOUGH, BARRY, ROGER;KILTY, IAIN, CHARLES;DAVIES, BARRY, ROBERT;SCHMIDT, GUENTER |
发明人 |
RUDLAND, PHILIP, SPENCER;BARRACLOUGH, BARRY, ROGER;KILTY, IAIN, CHARLES;DAVIES, BARRY, ROBERT;SCHMIDT, GUENTER |