摘要 |
An agent for inhibiting leukocyte invasion of tissues contains a hydroxyproline derivative of formula (I), in which R1 and R2 may be the same or different and stand for hydrogen, alkyl groups with 1 to 10 C atoms or an acyl group with 1 to 8 C atoms, R3 stands for a hydroxy, alkoxy or amino group which may have 1 or 2 alkyl substituents with 1 to 4 C atoms or 1 or 2 aryl substituents with 6 to 10 C atoms. Also disclosed is a pharmaceutically acceptable salt of this compound, optionally with other usual pharmaceutical additives and/or auxiliary substances. This agent is useful to prevent and heal damages to tissues caused by invasion and activation of leukocytes.
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申请人 |
CHEPHASAAR CHEM.-PHARM. FABRIK GMBH, 66386 ST INGBERT, DE |
发明人 |
BRUNE, KAY, PROF. DR.MED. DR.H.C., 91080 MARLOFFSTEIN, DE;HALLMANN, RUPERT, DR., 91341 ROETTENBACH, DE |