| 摘要 |
<p>A method and medicant for the inhibition of activation of the nuclear transcription NF-λB comprising administering an effective amount of a compound of formula (I) where R = ethylene, R´= C4 to C14 straight chain or branched alkyl, x is greater than 1, and y = 8 to 18, is provided. The medicant is preferably administered by aerosolization into the mammalian respiratory system. The medicant may also be applied to the mammalian skin. Preferably, the medicant includes a physiologically acceptable carrier which may be selected from buffered saline, isotonic saline, normal saline, petroleum-based ointments and U.S.P. cold cream. There is further provided a method wherein said medicant includes an anti-inflammatory steroid. In addition, a method and medicant for treating cutaneous inflammatory disorders, inhibiting the secretion of the pro-inflammatory cytokines TNF, IL-1, IL-6, IL-8 and the growth factor GM-CSF, is provided.</p> |
