METHODS OF DIAGNOSING A CLINICAL SUBTYPE OF CROHN'S DISEASE WITH FEATURES OF ULCERATIVE COLITIS

摘要

The present invention provides a method of diagnosing a clinical subtype of Crohn's disease (CD) by determining whether perinuclear anti-neutrophil antibodies (pANCA) are present in a patient with CD, where the presence of pANCA indicates the clinical subtype of CD with features of ulcerative colitis (UC). The invention also provides a method of diagnosing a clinical subtype of CD by detecting an Arg<241> allele at an ICAM-1 locus in a patient with CD, where the Arg<241> allele indicates a clinical subtype of CD with features of ulcerative colitis. In addition, the invention provides a method of diagnosing a pANCA-positive subtype of CD by detecting an Arg<241> allele at an ICAM-1 locus in a patient with CD, where the Arg<241> allele indicates the pANCA-positive subtype of CD.