发明名称 |
SETT ATT FRAMSTELLA 5-(1,1-DIFENYL-3-(5 ELLER 6-HYDROXI-2-AZABICYKLO-(2,2,2)OKT-2-YL)PROPYL)-2-ALKYL-1,3,4-OXADIAZOLER OCH DERMED BESLEKTADE FORENINGAR |
摘要 |
This invention encompasses novel 5-¢1,1-diphenyl-3-(5-or 6-hydroxy-2-azabicyclo¢2.2.2!oct-2-yl)-propyl!-2-alkyl-1,3,4-oxadiazoles and their lower Oalkanoyl derivatives. These compounds are useful antidiarrheal agents and also possess little or no analgesic activity. These compounds are prepared by reacting the appropriate tetrazoles in the presence of a solvent such as pyridine with a suitable anhydride or acid chloride to give the oxadiazoles, optionally followed by alkaline hydrolysis to yield the 5-or 6-hydroxy compounds. |
申请公布号 |
SE7702640(A) |
申请公布日期 |
1977.09.11 |
申请号 |
SE19770002640 |
申请日期 |
1977.03.09 |
申请人 |
G D * SEARLE & CO |
发明人 |
G W * ADELSTEIN;A * KARIM;C H * YEN |
分类号 |
A61K31/435;A61P1/12;C07D303/40;C07D453/06;(IPC1-7):07D271/10 |
主分类号 |
A61K31/435 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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