| 发明名称 |
IN VIVO GENE TRANSFER METHODS FOR WOUND HEALING |
| 摘要 |
The present invention relates to an in vivo method for specific targeting and transfer of DNA into mammalian repair cells. The transferred DNA may include any DNA encoding a therapeutic protein of interest. The invention is based on the discovery that mammalian repair cells proliferate and migrate into a wound site where they actively take up and express DNA. The invention further relates to pharmaceutical compositions that may be used in the practice of the invention to transfer the DNA of interest. Such compositions include any suitable matrix in combination with the DNA of interest.
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| 申请公布号 |
CA2251655(A1) |
申请公布日期 |
1997.10.23 |
| 申请号 |
CA19972251655 |
申请日期 |
1997.04.11 |
| 申请人 |
THE REGENTS OF THE UNIVERSITY OF MICHIGAN |
发明人 |
GOLDSTEIN, STEVEN A.;BONADIO, JEFFREY |
| 分类号 |
A61K47/02;A61K9/00;A61K38/00;A61K38/18;A61K38/19;A61K38/20;A61K38/22;A61K38/29;A61K47/42;A61K47/48;A61K48/00;A61L17/00;A61L27/00;A61P17/02;A61P17/06;A61P43/00;C07K14/47;C07K14/51;C07K14/635;C07K14/72;C07K14/78;C12N15/12;C12N15/87;(IPC1-7):C12N15/87;C12N15/18;A61K31/70;C12N15/85 |
主分类号 |
A61K47/02 |
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