发明名称 |
Method of preparing D-amino acid-N-(S)- alpha -alkylbenzylamide |
摘要 |
L-amino acid amides are converted to the corresponding D-amino acid amides. An amide formed from an L-amino acid and an optically active (S)- alpha -alkylbenzylamine is subjected to dehydration condensation with an aryl aldehyde to form a Schiff's base, which is racemized at the amino acid moiety in the presence of a base to yield an N-allylidene-D-amino acid-(S)-amide. The less-soluble diastereomer N-allylidene-D-amino acid-(S)-amide is crystallized from the reaction mixture and recovered by means of solid/liquid separation. The N-allylidene form is readily hydrolyzed into the amino acid-(S)-amide and the starting aldehyde.
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申请公布号 |
US5679857(A) |
申请公布日期 |
1997.10.21 |
申请号 |
US19950558663 |
申请日期 |
1995.11.16 |
申请人 |
AJINOMOTO CO., INC. |
发明人 |
HIJIYA, TOYOTO;MOCHIZUKI, CHIAKI;TAKEMOTO, TADASHI |
分类号 |
C07B53/00;C07C231/12;C07C231/16;C07C237/06;(IPC1-7):C07C231/18 |
主分类号 |
C07B53/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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