| 摘要 |
A pharmaceutically efficacious pteridine compound of formula I: (see fig.I) wherein A denote a bridging hydrocarbon group containing 1 to 8 carbon atoms and containing a (see fig.II) group directly bonded to the phenyl group and one of the methylene radicals of the bridging A group is optionally replaced by -O-;R1 is hydrogen, a cycloalkyl group with up to 7 carbon ring atoms, or an alkyl group having 1 to 6 carbon atoms, benzyl, or aryl; R2 is hydrogen or an alkyl group having 1 to 6 carbon atoms, or wherein R1 and R2 together form a five- or six-membered heterocyclic group which optionally contains additional hereto atoms selected from the group consisting of nitrogen, oxygen, and sulfur; R3 is hydrogen or an alkyl group having 1 to 3 carbon atoms; R~ is hydrogen, an optionally substituted alkyl group having 1 to 3 carbon atoms, carboxyl, hydroxyl or R3 and R~ together with the carbon atom to which they are attached form a cycloalkyl group and the pharmaceutically acceptable acid addition salts thereof.
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