发明名称 |
Pharmaceutical composition comprising diclofenac and cyclodextrin |
摘要 |
A method of preparing an injectable pharmaceutical or veterinary composition which comprises either diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, or an inclusion complex of diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, includes the step of dissolving either the diclofenac or salt thereof and the 2-hydroxypropyl beta-cyclodextrin, or the inclusion complex, in water to form a solution, the water having been acidified to a pH such that the pH of the solution is from 6.0 to 8.5 inclusive, in the absence of a phosphate buffer. The composition so produced has good stability on storage.
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申请公布号 |
US5679660(A) |
申请公布日期 |
1997.10.21 |
申请号 |
US19940352866 |
申请日期 |
1994.12.02 |
申请人 |
FARMARC NEDERLAND BV |
发明人 |
BODLEY, MARK DAVID;GLINTENKAMP, LUETA ANN;PENKLER, LAWRENCE JOHN;VAN OUDTSHOORN, MICHIEL COENRAAD BOSCH |
分类号 |
A61K9/08;A61K31/19;A61K31/195;A61K47/40;A61K47/48;A61P25/04;A61P29/00;(IPC1-7):A61K31/715;A61K31/135 |
主分类号 |
A61K9/08 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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