Tricyclic compounds capable of inhibiting tyrosine kinases of the epidermal growth factor receptor family

摘要

Novel 4-substituted amino benzothieno[3,2-d]pyrimidine and 4-substituted amino[2,3-d]pyrimidine inhibitors of epidermal growth factor receptor family of tyrosine kinases are described, as well as pharmaceutical compositions of the same, which are useful in treating proliferative diseases such as cancer, synovial pannus invasion in arthritis, psoriasis, vascular restenosis and angiogenesis and additionally useful in the treatment of pancreatitis and kidney disease as well as a contraceptive agent.