Cyclosporin a formulations as nanoparticles

摘要

Cyclosporin A formulations are provided as amorphous nanoparticle dispersions for physiologic absorption.. The compositions have high bioavailability and patient acceptability. By providing for concentrates comprising lower alkanols and a polyoxyalkylene surfactant as a stable dispersion of cyclosporin A, upon introducing the stable dispersion into an aqueous medium, the subject formulation is produced comprising amorphous bioavailable cyclosporin nanoparticles.