| 摘要 |
PCT No. PCT/GB97/00651 Sec. 371 Date Oct. 8, 1998 Sec. 102(e) Date Oct. 8, 1998 PCT Filed Nov. 3, 1997 PCT Pub. No. WO97/35869 PCT Pub. Date Oct. 2, 1997A compound which is a dinucleotide analogue of formula or a salt thereof, where B1 and B2 are each independently a monovalent nucleoside base radical, R1 is hydrogen or Y1, R2 and R3 are each independently hydrogen, halogen, hydroxy or -OY2, R4 is hydrogen, halogen, hydroxy, -OY3 or R7, R5 is hydrogen, halogen or R8, R6 is hydrogen, Y4 or a phosphoramidyl group, Z is a group of formula II, III or IV where R9 is hydrogen, halogen, hydroxy, -OY5 or R13, R10 is hydrogen, halogen or R14, R11 is hydroxy, R15 or -OR15 where R15 is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, and R12 is hydrogen, R12a or -OCOR12a where R12a is a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group, Y1, Y2, Y3, Y4 and Y5 are each indpendently a hydroxy-protecting group, and R7, R8, R13 and R14 are each independently a C1 to C10 aliphatic group, a C3 to C8 cycloaliphatic group, a C6 to C10 aromatic group or a C7 to C13 araliphatic group. |
