发明名称 |
USES OF ONCOFETAL ANTIGEN SPECIFIC CD4, CD8 CYTOTOXIC AND SUPPRESSOR T CELLS AND INTERLEUKIN-10 |
摘要 |
The present invention provides a method of determining the success of a cancer therapy in an individual, comprising the step of measuring the frequency of occurrence of an oncofetal antigen-specific subclasses in the individual's peripheral blood. Also provided is a method of determining whether protective immunity against a tumor will develop in an individual, comprising the step of measuring the frequency of oncofetal antigen-specific T cells, tumor cells and macrophages at the site of the tumor which secrete IL-10. Additionally, a method of determining whether an individual having a tumor will go into remission or remain in remission, comprising the step of measuring the frequency of oncofetal antigen-specific Th1 cells, Tc cells and Ts cells, IL-10 and interferon- gamma secreting T cells in the peripheral blood.
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申请公布号 |
WO9738089(A1) |
申请公布日期 |
1997.10.16 |
申请号 |
WO1997US05685 |
申请日期 |
1997.04.04 |
申请人 |
SOUTH ALABAMA MEDICAL SCIENCE FOUNDATION |
发明人 |
COGGIN, JOSEPH, H.;BARSOUM, ADEL, L.;ROHRER, JAMES, W. |
分类号 |
A61K38/17;C07K16/24;G01N33/574;(IPC1-7):C12N5/00;C12N5/02;A61K39/00;A61K35/14;A01N63/00 |
主分类号 |
A61K38/17 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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