6-SUBSTITUTED AMINO-4-OXA-1-AZABICYCLO[3,2,0]HEPTAN-7-ONE DERIVATIVES AS CYSTEINE PROTEASE INHIBITORS

摘要

Novel 6-substituted amino-4-oxa-1-azabicyclo¢3,2,0! heptan-7-one compounds, as well as the pharmaceutically acceptable salts thereof and diastereoisomers thereof, of formula (I) are disclosed, which exhibit excellent cysteine protease inhibitory activity and my be used for treatment of different diseases such as muscular dystrophy, arthritis, myocardial infarction, Alzheimer's disease, bacterial infection, common cold, osteroporosis and cancer metastasis.