发明名称 |
Process for the production of oligopeptid-aldehydes |
摘要 |
Preparation of a reversibly protected oligopeptide aldehyde (I) comprises: (a) dissolving an N-terminal-end reversibly protected oligopeptide alcohol in a buffered solvent mixture containing a non-oxidisable, polar, water immiscible solvent and a small amount of water; (b) adding a stoichiometric amount of sodium bromide; (c) oxidising the alcohol under cooling using a catalytic amount of 2,2,6,6-tetramethylpiperidinoxyl (TEMPO) and/or its derivative; (d) adding an aqueous sodium hypochlorite solution to the reaction suspension; and (e) ending the reaction by adding a reducing agent.
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申请公布号 |
EP0801073(A2) |
申请公布日期 |
1997.10.15 |
申请号 |
EP19970101088 |
申请日期 |
1997.01.24 |
申请人 |
HOECHST AKTIENGESELLSCHAFT |
发明人 |
RYBCZYNSKI, WOLFGANG, DR.;KESSELER, KURT, DR. |
分类号 |
C07K1/06;C07K1/107;C07K1/113;C07K5/027;C07K5/083;C07K5/087;C07K5/09;C07K5/107;(IPC1-7):C07K5/08;C07K5/10;C07K1/02 |
主分类号 |
C07K1/06 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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