发明名称 |
Selective photoinduced flavin-dependent cleavage of rna at g-u base pairs |
摘要 |
A method of and a kit for cleaving an RNA molecule containing at least one G-U wobble base pair at the at least one G-U wobble base pair thereof, comprising combining the RNA molecule with (a) a photosensitizing flavin derivative which is capable of performing a photooxidative reaction with the RNA molecule upon irradiation with light and (b) a divalent metal cation, or salt thereof, to produce a mixture; and thereafter cleaving the RNA molecule at the at least one G-U wobble base pair thereof by irradiating the mixture with light.
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申请公布号 |
EP0801072(A2) |
申请公布日期 |
1997.10.15 |
申请号 |
EP19970104262 |
申请日期 |
1997.03.13 |
申请人 |
ROCHE DIAGNOSTICS GMBH |
发明人 |
FAMULOK, MICHAEL, PROF. DR.;BURGSTALLER, PETRA, DR. |
分类号 |
C12N15/09;A61K41/00;C07H21/02;C12Q1/68;(IPC1-7):C07H21/02;C12N15/11 |
主分类号 |
C12N15/09 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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