| 摘要 |
<p>NEW MATERIAL:A compound (salt) of formula I [X is glycine residue or beta- alanine residue; Y is arginine residue or lysine residue; Z is single bond, proline residue, etc.; R<1> and R<2> are H, lower alkyl, cyclic alkyl or aryl, or R<1> and R<2> together form group of formula II (R<3> and R<4> are H, lower alkyl, OH, etc.; m and n are 0-5 but are simultaneously not 0), etc.]. USE:An anticoagulant. PREPARATION:For example, a C-terminated amino acid whose alpha-amino group is protected is dissolved in a solvent such as DMF and reacted with isobutyl chloroformate in the presence of triethylamine and a dialkylamine. After the alpha-amino group-protecting group is removed from the reaction product, the reaction product is reacted in turn in accordance with the amino acid sequence of the peptide to synthesize the peptide chain, followed by removing the protecting groups of the protected peptide to provide the proline-containing peptide of formula I.</p> |
