发明名称 Method to increase the stability of nanocapsules during storage thereof
摘要 <p>It comprises: adding a cryoprotective agent into an aqueous dispersion of the cited nanocapsules maintaining gentle stirring until the same dissolves totally. Afterwards, the dispersion thus obtained is subjected to freezing at a temperature no lower than -40o C for about 2 to 4 hours, and, finally, eliminating the water by heating it progressively to a temperature of about 35o C and at reduced pressure, whereby a stable lyophilized product is obtained. It can be conveniently reconstituted by adding water or a more complex aqueous solution to it. Nanocapsules are used in medicine, pharmacy, cosmetics, chemical industry, agriculture, veterinary science, etc.</p>
申请公布号 EP0621073(B1) 申请公布日期 1997.10.15
申请号 EP19940200884 申请日期 1994.03.30
申请人 LABORATORIOS CUSI, S.A. 发明人 GALAN VALDIVIA, FRANCISCO JAVIER;COLL DACHS, ANNA;CARRERAS PERDIGUER, NURIA
分类号 A61K9/51;A61K47/26;B01J13/20;(IPC1-7):B01J13/20 主分类号 A61K9/51
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