| 摘要 |
PROBLEM TO BE SOLVED: To obtain a mitomycin C derivative containing a highly unsaturated fatty acid residue, excellent in inhibitory action on nonreceptor type tyrosine kinase related to a cancer and an immunological disease, useful as a carcinostatic agent, a therapeutic agent for an immunological disease. SOLUTION: This mitomycin C derivative is shown by the formula (RCO is an n-3-based highly unsaturated fatty acid acyl residue; Me is methyl), is excellent in inhibitory activity against nonreceptor type tyrosine kinase related to a cancer and an immunological disease and is useful as a carcinostatic agent, a therapeutic agent for an immunological disease, etc. The compound is obtained by adding a solution of docosahexaenoic acid in ethyl acetate to a solution of diisopropylcarbodiimide in ethyl acetate at 0 deg.C, stirring at 0 deg.C for 30 minutes, adding mitomycin C and further reacting at room temperature for 24 hours. |
