| 发明名称 |
Amino acid amides of 1,3,4-thiadiazoles as matrix metalloproteinase |
| 摘要 |
Amino acid amides of 5-amino-1,3,4-thiadiazole-2-thione are disclosed. These compounds inhibit matrix metalloproteinase enzymes and cartilage degradation. Methods of treating diseases caused by over-activity of matrix metalloproteinases, such as osteoarthritis and rheumatoid arthritis, are also disclosed.
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| 申请公布号 |
US5677282(A) |
申请公布日期 |
1997.10.14 |
| 申请号 |
US19950473143 |
申请日期 |
1995.06.07 |
| 申请人 |
PROSCRIPT, INC. |
发明人 |
OLEKSYSZYN, JOZEF;JACOBSON, ALAN R. |
| 分类号 |
A61K31/41;A61K31/4245;A61K31/433;A61K38/00;A61P29/00;A61P35/00;A61P43/00;C07D271/10;C07D285/12;C07D285/135;C07D417/12;C07K5/06;C07K5/062;C07K5/065;C07K5/072;C07K5/078;C07K5/087;C07K5/09;C07K5/097;C07K5/103;C07K5/117;(IPC1-7):C07K5/08 |
主分类号 |
A61K31/41 |
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