Benzazepine-, benzoxazepine- and benzothiazepine-n-acetic acid derivatives, process for their preparation and pharmaceutical compositions containing them

摘要

Compounds with neutral endopeptidase (NEP) inhibitory activity corresponding to the formula I <IMAGE> I in which R1 is a lower alkoxy-lower-alkyl group whose lower alkoxy radical is substituted by a lower alkoxy group, or a phenyl-lower-alkyl or phenyloxy-lower-alkyl group which can optionally be substituted in the phenyl ring by lower alkyl, lower alkoxy or halogen, or a naphthyl-lower-alkyl group, A is CH2, O or S, R2 is hydrogen or halogen, R3 is hydrogen or halogen, R4 is hydrogen or a group forming a biolabile ester, and R5 is hydrogen or a group forming a biolabile ester, and the physiologically acceptable acid addition salts thereof.