| 摘要 |
PCT No. PCT/US93/07307 Sec. 371 Date Apr. 26, 1995 Sec. 102(e) Date Apr. 26, 1995 PCT Filed Aug. 3, 1993 PCT Pub. No. WO94/03469 PCT Pub. Date Feb. 17, 1994Provided are new derivatives of neuraminic acid of formula (I), where Ac represents an acyl residue of an aliphatic, araliphatic, aromatic, alicyclic, or heterocyclic carboxylic acid, including carboxylic amides, their 2-hydrocarbyl-glycosides, and their peracylated derivatives at the hydroxy groups of both these series of amides. These compositions are therapeutically useful in providing a protective effect against the neurotoxicity induced by excitatory amino acids, and can therefore be used in therapies of the central nervous system.
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