发明名称 |
CHO cells that express human LH-RH receptor |
摘要 |
Disclosed are CHO cells which are capable of continued production of human LH-RH receptor proteins, or cell membrane fractions thereof; recombinant human LH-RH receptor proteins or partial peptides thereof; methods for screening compounds which have affinity for an LH-RH receptor by contacting the compound with the CHO cells or the cell membrane fractions thereof, or the recombinant human LH-RH receptor proteins or the partial peptides thereof; kits for screening them; the compounds which have affinity for the LH-RH receptor obtained by methods for the screening or kits for the screening; and pharmaceutical compositions containing the compound, thereby being able to early provide prophylactic or therapeutic compositions, for example, for prostate cancer, uterine cancer, breast cancer, a pituitary tumor, endometriosis, hysteromyoma or precocious puberty. They are also useful as a pregnancy controlling composition such as contraceptive or a menstrual cycle controlling composition.
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申请公布号 |
US5677184(A) |
申请公布日期 |
1997.10.14 |
申请号 |
US19950423691 |
申请日期 |
1995.04.18 |
申请人 |
TAKEDA CHEMICAL INDUSTRIES, LTD. |
发明人 |
ONDA, HARUO;OHKUBO, SHOICHI;HINUMA, SHUJI;SAWADA, HIDEKAZU |
分类号 |
A61K38/00;A61K39/00;C07K7/23;C07K14/72;C12N15/12;G01N33/53;(IPC1-7):C12N15/85 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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