| 摘要 |
The present invention relates to a novel class of phenylboronic acid bioconjugate complexes derived from aminosalicylic acid, and the method of making and using such bioconjugate complexes. The bioconjugate complexes are in the form of the following general formulas; <IMAGE> General Formula I GE> General Formula III +TR <IMAGE> <IMAGE> General Formula IV +TR <IMAGE> wherein group X is selected from the group consisting of O, NH, N-alkyl, NC6H5, N-aryl, NCH2-aryl, NCH2CH2OH, NCOCH2CH2OH, NOH, NO-alkyl and NOCH2-aryl, wherein alkyl denotes a hydrocarbon moiety of from 1 to 4 carbons in length and which may be linear or branched, wherein aryl is selected from the group consisting of an aromatic ring, a substituted aromatic ring and a fused aromatic ring, wherein group Y is selected from the group consisting of O, S, NH, N-alkyl, N-aryl and NCH2-aryl, wherein groups Z and Z* comprise a spacer selected from an alkyl and a polyethyleneglycol chain, of from 1 to 16 carbon equivalents in length, wherein the chain may contain intermediate amide and disulfide bonds, and and wherein gro
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