The present invention provides novel conjugates of a synthetic polypeptide containing RGD or (dR)GD and a biodegradable polymer, hyaluronate. The conjugates are prepared by any one of three different methods provided by the present invention: (1) an epoxide method (2) a sodium periodate method, and (3) a tresyl chloride method. The conjugates prepared by these methods are useful to aid in wound healing and tissue regeneration by providing a temporary matrix for tissue repair. The invention also provides novel RGD-peptides.
申请公布号
US5677276(A)
申请公布日期
1997.10.14
申请号
US19950469582
申请日期
1995.06.05
申请人
LA JOLLA CANCER RESEARCH FOUNDATION
发明人
DICKERSON, KENNETH T.;GLASS, JAMES R.;LIU, LIN-SHU;POLAREK, JAMES W.;CRAIG, WILLIAM S.;MULLEN, DANIEL G.;CHENG, SOAN