PRODUCTION OF FLUOXETINE AND NEW INTERMEDIATES

摘要

4-methyl-3-¢(4-trifluormethyl)phenoxy!-3-phenyl propylamine (I) is prepared by reacting 3-dimethylamino-1-phenyl-1-propanol (III) with haloformate (VIII) to obtain a substituted propyl carbamate (IX) which is hydrolyzed under basic conditions to yield methylamino-1-phenyl-1-propanol (X). The methylamino-1-phenyl-1-propanol is then converted to fluoxetine (I) by reaction with 4-halo-benzotrifluoride (XI). In the process certain substituted carbamates are obtained as intermediates.