发明名称 |
Styryl-substituted monocyclic and bicyclic heteroaryl compounds which inhibit EGF receptor tyrosine kinase |
摘要 |
Methods of inhibiting cell proliferation in a patient suffering from such disorder comprising the use of a styryl-substituted heteroaryl compound wherein the heteroaryl group is a monocyclic ring with 1 or 2 heteroatoms, or a bicyclic ring with 1 to about 4 heteroatoms, said compound optionally substituted or polysubstituted, with the proviso that when said ring is polysubstituted, the substituents do not have a common point of attachment to said ring, and those compounds wherein no substituent on the heteroaryl group is a carboxy group or an ester group, and pharmaceutical compositions comprising such compounds.
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申请公布号 |
US5677329(A) |
申请公布日期 |
1997.10.14 |
申请号 |
US19950445047 |
申请日期 |
1995.05.19 |
申请人 |
RHONE-POULENC RORER PHARMACEUTICALS, INC. |
发明人 |
SPADA, ALFRED P.;PERSONS, PAUL E.;LEVITZKI, ALEXANDER;GILON, CHAIM;GAZIT, AVIV |
分类号 |
A61K31/404;A61K31/4406;C07D209/18;C07D213/57;C07D213/89;(IPC1-7):C07D209/04;A61K31/40 |
主分类号 |
A61K31/404 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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