Use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16

摘要

The invention relates to the use of peptide derivatives for the preparation of medicaments inhibiting endopeptidases 24.15 and 24.16. These peptide derivatives are in accordance with the formula: <IMAGE> (I) in which R1 is an optionally substituted aralkyl group, R2 is Pro, Hyp, thiazolidine or dehydroproline, R3 is H or an alkyl radical, R4 is an alkyl group or the side chain of an amino acid, R5 and R6 can be H, NH4+ or metals and R7 is H or CH3. N-(phenylethylphosphonyl)-Gly-Pro-aminohexanoic acid and N-(phenylethyl phosphonyl)-Ala-Pro-aminohexanoic acid are examples of effective derivatives.